Cellestia Biotech is pioneering innovative therapeutics based on novel modes of action to treat autoimmune diseases and multi-drug resistant cancers. Our clinical stage drug candidate, CB-103, has demonstrated both safety and biological activity in humans. Along with ongoing Phase 2 IITs for multi-drug resistant cancers, CB-103 is also poised to enter a Proof-of-Concept clinical study for graft-versus-host disease (GvHD).

Our leading compound, CB-103, specifically targets CSL-NOTCH transcription complex. There is compelling genetic and pharmacological validation for involvement of CSL- NOTCH transcription complex in autoimmune and inflammatory diseases (AIID) through regulation of Treg cells, T effector cells and cytokine. Furthermore, CB-103 has exhibited proof-of-concept efficacy in animal models for graft-versus-host disease (GvHD) prophylaxis.

Similarly in human cancers, activation of CSL-NOTCH transcription complex due to gain of function mutations in NOTCH receptors is known to impinge on several hallmarks of cancer (such as proliferation, evading cell death, promoting metastasis and drug resistance).

Despite importance of this signalling cascade in human diseases, clinical development of NOTCH inhibitors had been impeded due to severe dose limiting toxicities. Cellestia’s approach has proven to overcome these dose limiting toxicities and thereby holds the potential to address both the multi-billion-dollar oncology and autoimmune markets.

With an Investigational New Drug (IND) approval in place, CB-103 is ready to proceed to Proof-of-Concept clinical studies for GvHD, paving the way for subsequent registrational trials in GvHD prophylaxis. Additionally, our Phase 2 trials have successfully treated patients with multi-drug resistant cancers, demonstrating CB-103’s efficacy in challenging therapeutic scenarios.

In parallel, we are closely following the clinical candidate with a range of pre-clinical candidates for chronic autoimmune indications such as psoriasis, Sjogren’s syndrome, systemic lupus erythematosus (SLE), inflammatory bowel disease (IBD), and giant cell arteritis. These pre-clinical candidates are on track to enter IND-enabling studies and anticipate entering First-in-Human (FIH) studies within the next 12-18 months.


Based on more than 10 years of academic research led by the company’s CEO, Rajwinder Lehal, Cellestia was founded in 2014 as spin-off from the prestigious Swiss Institute for Experimental Cancer Research (ISREC), based at the École Polytechnique Fédérale de Lausanne (EPFL), a world-renowned centre of excellence in Switzerland. Originally incubated at ISREC, today Cellestia has established its independent research facilities at Biopôle in Lausanne and in close proximity to Ludwig Institute for Cancer Research, Swiss Cancer Center Léman, Le Centre hospitalier universitaire vaudois (CHUV), and University of Lausanne and EPFL. In addition, multiple international research collaborations have been established.



Transcription Factors Inhibitors Research starts with Raj Lehal’s doctoral thesis


First patent application filed


Foundation of Cellestia in Lausanne


Michael Bauer joins
and the HQ move to Basel


• CB-103 development begins
• First series financing and team expansion


• IND filed
• Mode of action identified


• Start of Clinical Development in Oncology
• Series A completed


• Safety and Efficacy Data
• Series B completed


Clinical Proof of Concept CB-103


• Start of Phase II Oncology
• Global Expansion of Development Program CB-103

Clinical & Research Collaboration

Cellestia has established a global clinical development and research collaboration with Europe, US and Asia.

MD Anderson Cancer Network
Adenoid Cystic Carcinoma Research Foundation
University of Cincinnati
IOR - Institute of Oncology Research
Universitats Kinderspital Zurich
Swiss Institute of Bioinformatics
Universitatsklinikum Schleswig-Holstein
The Christie NHS Foundation Trust
Harvrad Medical School
Penn - Univesity of Pennsylvania
LSU Health - New Orleans
Unil - Université de Lausanne
Brigham Health - Brigham and Women's Hospital